Whooping cough vaccination in pregnancy; the evidence

For a quick reference, the CDC has also published links to the evidence on its website.

For more detail, here follows a selection of some of the current scientific evidence for the safety and effectiveness of the whooping cough vaccine in pregnancy.

• Donegan, Katherine, Bridget King, and Phil Bryan. “Safety of pertussis vaccination in pregnant women in UK: observational study.” Bmj 349 (2014): g4219.

• Kharbanda, E. O., Vazquez-Benitez, G., Lipkind, H. S., Klein, N. P., Cheetham, T. C., Naleway, A., … & Nordin, J. D. (2014). Evaluation of the association of maternal pertussis vaccination with obstetric events and birth outcomes. JAMA, 312(18), 1897-19

• Morgan, J. L., Baggari, S. R., McIntire, D. D., & Sheffield, J. S. (2015). Pregnancy Outcomes After Antepartum Tetanus, Diphtheria, and Acellular Pertussis Vaccination. Obstetrics & Gynecology, 125(6), 1433-1438.

• Munoz, F. M., Bond, N. H., Maccato, M., Pinell, P., Hammill, H. A., Swamy, G. K., … & Baker, C. J. (2014). Safety and Immunogenicity of Tetanus, Diphtheria, and Acellular Pertussis Immunization During Pregnancy in Mothers and Infants: A Randomized Clinical Trial. Obstetrical & Gynecological Survey, 69(9), 517-519.

• Sukumaran, L., McCarthy, N. L., Kharbanda, E. O., Weintraub, E. S., Vazquez-Benitez, G., McNeil, M. M., … & Orenstein, W. A. (2015). Safety of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis and Influenza Vaccinations in Pregnancy. Obstetrics & Gynecology, 126(5), 1069-1074.

• Sukumaran, L., McCarthy, N. L., Kharbanda, E. O., McNeil, M. M., Naleway, A. L., Klein, N. P., … & Omer, S. B. (2015). Association of Tdap Vaccination With Acute Events and Adverse Birth Outcomes Among Pregnant Women With Prior Tetanus-Containing Immunizations. JAMA, 314(15), 1581-1587.

• Amirthalingam, G., Andrews, N., Campbell, H., Ribeiro, S., Kara, E., Donegan, K., … & Ramsay, M. (2014). Effectiveness of maternal pertussis vaccination in England: an observational study. The Lancet, 384(9953), 1521-1528.

• Dabrera, G., Amirthalingam, G., Andrews, N., Campbell, H., Ribeiro, S., Kara, E., … & Ramsay, M. (2014). A case-control study to estimate the effectiveness of maternal pertussis vaccination in protecting newborn infants in England and Wales, 2012–2013. Clinical Infectious Diseases, ciu821.

• Winter, Kathleen, et al. “Effectiveness of Prenatal Versus Postpartum Tetanus, Diphtheria, and Acellular Pertussis Vaccination in Preventing Infant Pertussis.” Clinical Infectious Diseases 64.1 (2017): 3-8.

• Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis
  Roger Baxter, Joan Bartlett, Bruce Fireman, Edwin Lewis, Nicola P. Klein
  Pediatrics Apr 2017, e20164091; DOI: 10.1542/peds.2016-4091

• Winter, K., Cherry, J. D., & Harriman, K. (2016). Effectiveness of prenatal Tdap vaccination on pertussis severity in infants. Clinical Infectious Diseases, ciw633.

• Saul, Nathan, et al. “Effectiveness of maternal pertussis vaccination in preventing infection and disease in infants: The NSW Public Health Network case-control study.” Vaccine(2018).

Page reviewed March 2018